Mechanisms of Cerebral Edema Leading to Early Seizures After Traumatic Brain Injury

Epidemiological data support a link between traumatic brain injury (TBI) and seizures. TBI accounts for approximately 16 % of acute symptomatic seizures which usually occur in the first week after trauma. Children are at higher risk for posttraumatic seizures than adults and experience greater morbidity and mortality from cerebral edema (CE). CE is responsible for half of the mortality associated with TBI. A recent book chapter summarizes the most important features of posttraumatic seizure. In this chapter we will summarize features relevant to the link between cerebral edema, cerebrovascular events and seizures after TBI. In addition, we will discuss the potential autoimmune implications of TBI.